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Что (кто) такое methylated DNA - определение
Methylated DNA immunoprecipitation
PURIFICATION TECHNIQUE
Methylated dna immunoprecipitation; MeDIP; Methylated DNA
Methylated DNA immunoprecipitation (MeDIP or mDIP) is a large-scale (chromosome- or genome-wide) purification technique in molecular biology that is used to enrich for methylated DNA sequences. It consists of isolating methylated DNA fragments via an antibody raised against 5-methylcytosine (5mC).
DNA methylation
![Representation of a [[DNA]] molecule that is methylated. The two white spheres represent [[methyl group]]s. They are bound to two [[cytosine]] [[nucleotide]] molecules that make up the DNA sequence.](https://commons.wikimedia.org/wiki/Special:FilePath/DNA methylation.jpg?width=200 "Representation of a [[DNA]] molecule that is methylated. The two white spheres represent [[methyl group]]s. They are bound to two [[cytosine]] [[nucleotide]] molecules that make up the DNA sequence.")
![Possible pathways of cytosine methylation and demethylation. Abbreviations: [[S-Adenosyl-L-homocysteine]] ('''SAH'''), [[S-adenosyl-L-methionine]] ('''SAM'''), [[DNA methyltransferase]] ('''DNA MTase'''), [[Uracil-DNA glycosylase]] ('''UNG''')](https://commons.wikimedia.org/wiki/Special:FilePath/DNA methylation (corrected).png?width=200 "Possible pathways of cytosine methylation and demethylation. Abbreviations: [[S-Adenosyl-L-homocysteine]] ('''SAH'''), [[S-adenosyl-L-methionine]] ('''SAM'''), [[DNA methyltransferase]] ('''DNA MTase'''), [[Uracil-DNA glycosylase]] ('''UNG''')")
THE COVALENT TRANSFER OF A METHYL GROUP TO EITHER N-6 OF ADENINE OR C-5 OR N-4 OF CYTOSINE
Dna methylation; Methylome; Methylomics; Cytosine methylation; Dam dcm strain; Dna Methylation; Gene methylation; DNA cytosine methylation; DNA adenine methylation
DNA methylation is a biological process by which methyl groups are added to the DNA molecule. Methylation can change the activity of a DNA segment without changing the sequence.
O-methylated flavonoid
ANY FLAVONOID HAVING A METHYLATED HYDROXY GROUP
O-methylated flavonoids; Methylated flavonol; O-methylated flavone; O-methylated flavanone; O-methylated flavanonol; O-methylated Anthocyanidin; O-methylated anthocyanidin; O-methylated flavonol; O-methylated isoflavone; Methoxyflavonoids; Methoxyflavonoid; Methoxyflavone; O-methylated flavanol; PD 98059
The O-methylated flavonoids or methoxyflavonoids are flavonoids with methylations on hydroxyl groups (methoxy bonds). O-methylation has an effect on the solubility of flavonoids.
